Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells that expressed apolipoprotein E4 (ApoE4), a variant of the APOE gene product and the major genetic risk factor for AD, we demonstrated that ApoE4-expressing neurons had higher levels of tau phosphorylation, unrelated to their increased production of amyloid-β (Aβ) peptides, and that they displayed GABAergic neuron degeneration. ApoE4 increased Aβ production in human, but not in mouse, neurons. Converting ApoE4 to ApoE3 by gene editing rescued these phenotypes, indicating the specific effects of A...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer's dise...
Epidemiological studies have established that the epsilon 4 allele of the ApoE gene (ApoE4) constitu...
Epidemiological studies have established that the epsilon 4 allele of the ApoE gene (ApoE4) constitu...
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to ...
The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzhei...
Despite its clear impact on Alzheimer's disease (AD) risk, apolipoprotein (apo) E4's contributions t...
The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzhei...
BACKGROUND: The presence of an apolipoprotein E4 (ApoE4) genotype is the major genetic risk factor f...
BACKGROUND: The presence of an apolipoprotein E4 (ApoE4) genotype is the major genetic risk factor f...
Among the common apolipoprotein (apo) E isoforms (apoE2, apoE3, and apoE4), apoE4 is the major known...
Human induced pluripotent stem cells (hiPSCs) provide a unique opportunity to study the human specif...
Human induced pluripotent stem cells (hiPSCs) provide a unique opportunity to study the human specif...
Apolipoprotein (apo) E4 is a major risk factor for Alzheimer's disease, and many studies have sugges...
The epsilon 4 allele of the human apolipoprotein E gene (ApoE4) constitutes an important genetic ris...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s dise...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer's dise...
Epidemiological studies have established that the epsilon 4 allele of the ApoE gene (ApoE4) constitu...
Epidemiological studies have established that the epsilon 4 allele of the ApoE gene (ApoE4) constitu...
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to ...
The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzhei...
Despite its clear impact on Alzheimer's disease (AD) risk, apolipoprotein (apo) E4's contributions t...
The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzhei...
BACKGROUND: The presence of an apolipoprotein E4 (ApoE4) genotype is the major genetic risk factor f...
BACKGROUND: The presence of an apolipoprotein E4 (ApoE4) genotype is the major genetic risk factor f...
Among the common apolipoprotein (apo) E isoforms (apoE2, apoE3, and apoE4), apoE4 is the major known...
Human induced pluripotent stem cells (hiPSCs) provide a unique opportunity to study the human specif...
Human induced pluripotent stem cells (hiPSCs) provide a unique opportunity to study the human specif...
Apolipoprotein (apo) E4 is a major risk factor for Alzheimer's disease, and many studies have sugges...
The epsilon 4 allele of the human apolipoprotein E gene (ApoE4) constitutes an important genetic ris...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s dise...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer's dise...
Epidemiological studies have established that the epsilon 4 allele of the ApoE gene (ApoE4) constitu...
Epidemiological studies have established that the epsilon 4 allele of the ApoE gene (ApoE4) constitu...