Add to ORKGThe TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53 suppresses tumorigenesis by transcriptionally regulating a network of target genes that play roles in various cellular processes. Though originally characterized as a critical regulator for responses to acute DNA damage (activation of apoptosis and cell cycle arrest), recent studies have highlighted new pathways and transcriptional targets downstream of p53 regulating genomic integrity, metabolism, redox biology, stemness, and non-cell autonomous signaling in tumor suppression. Here, we summarize our current understanding of p53-mediated tumor suppression, situating recent findings from mouse models and unbiased screens in the context of previous studies and ...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53 suppresses tumori...
The p53 tumour suppressor is the most frequently mutated gene in human cancer. This transcription fa...
Abstract The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53 suppresses tumori...
The p53 tumour suppressor is the most frequently mutated gene in human cancer. This transcription fa...
Abstract The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulati...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cance...