In 2020, the UK government funded a portfolio of platform trials to develop new treatments for COVID-19. A key feature was the independent prioritization of candidate drugs with central coordination to prevent duplication, accelerating recruitment to deliver definitive trial results. A similar approach could be used for non-communicable diseases where treatment advances have been limited
Corona Virus Disease (COVID-19) drugs are not being developed at the pace in which the disease is sp...
Background There is an urgent unmet clinical need for the identification of novel therapeutics for ...
OBJECTIVES: To determine if a specific immunomodulatory intervention reduces progression of COVID-19...
In 2020, the UK government funded a portfolio of platform trials to develop new treatments for COVID...
In our 2020 consensus paper, we devised ten recommendations for conducting Complex Innovative Design...
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) Trial was set up in March 2020 to evaluate ...
The rapid global spread and significant mortality associated with the coronavirus disease (COVID-19)...
Funder: UKRIAbstract: Objectives: Stage 1: To evaluate the safety and efficacy of candidate agents a...
Objectives Stage 1: To evaluate the safety and efficacy of candidate agents as add-on therapies to s...
Clinical question: What is the role of drugs in the treatment of patients with covid-19?New recommen...
The coronavirus (SARS-CoV-2) emerged in December 2019 in Wuhan, China and by the end of April 2020, ...
BackgroundAn urgent need exists to rapidly screen potential therapeutics for severe COVID-19 or othe...
Background: Many available medicines have been evaluated as potential repurposed treatments for coro...
ObjectivesPhase I - To determine the optimal dose of each candidate (or combination of candidates) e...
The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high prevalence and eas...
Corona Virus Disease (COVID-19) drugs are not being developed at the pace in which the disease is sp...
Background There is an urgent unmet clinical need for the identification of novel therapeutics for ...
OBJECTIVES: To determine if a specific immunomodulatory intervention reduces progression of COVID-19...
In 2020, the UK government funded a portfolio of platform trials to develop new treatments for COVID...
In our 2020 consensus paper, we devised ten recommendations for conducting Complex Innovative Design...
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) Trial was set up in March 2020 to evaluate ...
The rapid global spread and significant mortality associated with the coronavirus disease (COVID-19)...
Funder: UKRIAbstract: Objectives: Stage 1: To evaluate the safety and efficacy of candidate agents a...
Objectives Stage 1: To evaluate the safety and efficacy of candidate agents as add-on therapies to s...
Clinical question: What is the role of drugs in the treatment of patients with covid-19?New recommen...
The coronavirus (SARS-CoV-2) emerged in December 2019 in Wuhan, China and by the end of April 2020, ...
BackgroundAn urgent need exists to rapidly screen potential therapeutics for severe COVID-19 or othe...
Background: Many available medicines have been evaluated as potential repurposed treatments for coro...
ObjectivesPhase I - To determine the optimal dose of each candidate (or combination of candidates) e...
The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high prevalence and eas...
Corona Virus Disease (COVID-19) drugs are not being developed at the pace in which the disease is sp...
Background There is an urgent unmet clinical need for the identification of novel therapeutics for ...
OBJECTIVES: To determine if a specific immunomodulatory intervention reduces progression of COVID-19...