Acanthocheilonema viteae in Mastomys coucha : Combination Effect of An Immunostimulator (CDRI compound 86/448) and Antifilarial agents on Establishment of Infection

Effect of two antifilarials ivermectin (microfilaricidal) and CDRI Comp. 82/437 (macrofilaricidal) in combination with immunostimulator (CDRI Comp. 86/448) was evaluated on establishment of Acanthocheilonema viteae infection in Mastomys coucha. The immunostimulator along with the antifilarials was administered on single occasion (Day 0 of larval exposure). Immunostimulator when given in combination with macrofilaricidal agent (82/437), revealed significantly less percentage of worm recovery over untreated control as well as over treated (with either immunostimulator or antifilarial alone) infected controls. It is, thus surmised that establishment of filarial infection is affected by immunostimulant along with antifilarial agent