Brugia malayi in Mastomys natalensis : Effect of Immunostimulators on Establishment and Course of Infection

Effect of three immunomodulators (IMS), muramyl dipeptide (MDP), Freund\u27s complete adjuvant (FCA) and a newly synthesized sugar free immunomodulator (CDRI Comp. No. 84/201) on the establishment and course of Brugia malayi infection in Mastomys natalensis was evaluated. These immunomodulators were administered on three occasions (days -10, 0 and +15 of larval exposure) by subcutaneous route. All the three immunostimulators caused prolongation of prepatent period of the infection, the longest being observed with Comp. 84/201 (136.6 days) followed by MDP (120 days) and FCA (118.82 days). Comp. 84/201 and MDP treated animals revealed significantly suppressed microfilaraemia (P