International audienceThe application-specific instruction set processors (ASIPs) have received more and more attention in recent years. ASIPs make trade-offs between flexibility and performance by extending the base instruction set of a general-purpose processor with custom functional units (CFUs). Custom instructions, executed on CFUs, make it possible to improve performance and achieve flexibility for extensible processors. The custom instruction synthesis flow involves two essential issues: custom instruction enumeration (subgraph enumeration) and custom instruction selection (subgraph selection). However, both enumerating all possible custom instructions of a given data-flow graph and selecting the most profitable custom instructions f...