Add to ORKGIdiopathic infertility is defined as the failure to achieve pregnancy after 12 months of unprotected sexual intercourse, without a known cause. Idiopathic infertility affects 15-30% of couples trying to conceive. Various aetiologies have been suggested as the cause of idiopathic infertility. In men and women, the immune system plays a role in conception, hence defects in this pathway could be a possible cause. Lifestyle and habits, such as having a high BMI or poor sleep quality, have also been suggested as being implicated in idiopathic infertility. Diagnosis requires a thorough history and physical examination, followed by multiple diagnostic tests for women and semen analysis for men. Despite adequate diagnostic protocol, women are often...