The aim of this paper is to provide an overview of the geopolitical status of the Upper Tigris area in antiquity, with a special focus on the period between ca. 401 BCE and the 6th century CE. Despite the popular impression that this area had a distinctly Armenian character, a closer look at its history shows that it was rather a territory with many local geopolitical entities that many neighboring countries periodically fought to possess. This area was strategically significant as a transit region located on the crossroads of important long-distance communication lines. Likewise, its natural resources were undoubtedly crucial to the neighboring countries. Indeed, powerful neighbors around the Upper Tigris area, including Armenia, the Irani...