The Patagonian Andes have been used to illustrate the dependency of major topographic changes in response to glacial erosion processes dominating over tectonic deformation and uplift. Here, we investigate tectonic and glacial contributors to the erosion history and evolution of topography in the Patagonian Andes at 46.5°S. We present 33 new apatite and zircon (U‐Th)/He (AHe and ZHe, respectively) and fission track (AFT and ZFT, respectively) ages integrated with 46 previously published bedrock thermochronometric ages in a 3D thermo‐kinematic model. Observed thermochronometer ages increase from the eastern flank of the topographic crest of the orogen toward the eastern retro‐foreland basin (from AFT 4–10 Ma, ZHe 4–12 Ma, ZFT 6–14 Ma to AFT 2...