D-Serine (D-Ser) and D-aspartate (D-Asp) act as neuromodulators of N-methyl-D-aspartate receptors, which are involved in several neuropsychiatric pathologies, including Alzheimer’s disease (AD). To clarify whether these molecules are deregulated in AD, serum levels of Ser and Asp enantiomers were determined by HPLC. The obtained results indicated a significant correlation between D-Ser level and AD, allowing to propose this parameter as a novel biomarker for AD diagnosis. In humans, little is known about D-Asp metabolism: its synthetic pathway is still unclear while the flavoenzyme D-aspartate oxidase (DASPO) is known to be responsible for its degradation. The studies carried out during my PhD project aimed at shedding light o...