The increasing trend of outsourcing hardware designs to offshore foundries for fabrication cost reduction has raised several security concerns related to intellectual property (IP) piracy, reverse engineering, counterfeiting, etc. The exposure of chip designs to a potentially malicious offshore foundry is of major concern for both government and private organizations and hence, there has been extensive research on security and privacy issues of integrated circuit (IC) supply chain. In this dissertation, we study the effectiveness of hardware-oriented obfuscation approaches for enhancing security and trust at different levels of design abstractions. At the circuit-level of design abstraction, we analyze the security offered by state-of-the-...