Study of Zn(II)-coumarin complex by electrochemical method with increased anticoagulant potency

The formation of complexes of coumarin and Zn(II) was studied in aqueous media at pH 8.2±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between coumarin and Zn(II). Coumarin produces a well-defined direct current polarogram and differential pulse polarogram in 1 m ammonium tartrate (supporting electrolyte) at pH 8.2±0.1. The stoichiometry of the Zn(II)-coumarin complex is 1:1. Anticoagulant studies on the drug and its metal complex have been performed in albino mice, revealing the complex to be more potent in anticoagulation activity compared to the parent drug