Growing evidences have recently pointed out disturbances of protein O-GlcNAcylation as a possible link between altered brain metabolism and the progression of neurodegenerative processes. As observed in Alzheimer’s disease (AD) brain, flaws of the cerebral glucose uptake translate into reduced HBP flux thus leading to impaired protein O-GlcNAcylation. Notably, the nutrient-related reduction of O-GlcNAcylated proteins triggers an aberrant increase of tau and APP phosphorylation in AD brain, favouring the formation of toxic neurofibrillary tangles and β-amyloid plaques which contribute to disease pathogenesis. Given that Down syndrome (DS) and AD share similar metabolic alterations and common pathological markers within the brain, it is con...
Transcriptional regulation is an important component of the peripheral sensory neuronal response to ...
Malignant pleural mesothelioma (MPM) is a highly aggressive tumour arising from the mesothelial cell...
The E1B55k gene in adenovirus type 5 was studied by generating recombinant viruses in which the E1B5...
Growing evidences have recently pointed out disturbances of protein O-GlcNAcylation as a possible li...
Mycobacterium tuberculosis is a pathogen responsible for around 10 million new TB cases and 1.4 mill...
Neuronal circuits of fear and anxiety have been studied extensively not only to understand basic pri...
In the last decade, a number of results show the involvement of 5-HT7 receptor in many aspects of ne...
Introduction. Glycomic analysis allows investigating on the global glycome within body fluids (as se...
Oxidative stress is one of the cellular responses determined at early stages of toxicity and can be ...
Plant cells require considerable transcriptional reprograming to mount an effective response to path...
Background: Insulin sensitivity is impaired by PGE2, a major product of cyclooxygenase-2 (COX-2), wh...
Background: Insulin sensitivity is impaired by PGE2, a major product of cyclooxygenase-2 (COX-2), wh...
Pathological angiogenesis is an essential component of tumor growth, development, and metastasis for...
The plasma membrane is highly organized and within the plasma membrane proteins cluster into so-call...
Drug-induced liver injury (DILI) is a common form of adverse drug reaction (ADR) seen within the cli...
Transcriptional regulation is an important component of the peripheral sensory neuronal response to ...
Malignant pleural mesothelioma (MPM) is a highly aggressive tumour arising from the mesothelial cell...
The E1B55k gene in adenovirus type 5 was studied by generating recombinant viruses in which the E1B5...
Growing evidences have recently pointed out disturbances of protein O-GlcNAcylation as a possible li...
Mycobacterium tuberculosis is a pathogen responsible for around 10 million new TB cases and 1.4 mill...
Neuronal circuits of fear and anxiety have been studied extensively not only to understand basic pri...
In the last decade, a number of results show the involvement of 5-HT7 receptor in many aspects of ne...
Introduction. Glycomic analysis allows investigating on the global glycome within body fluids (as se...
Oxidative stress is one of the cellular responses determined at early stages of toxicity and can be ...
Plant cells require considerable transcriptional reprograming to mount an effective response to path...
Background: Insulin sensitivity is impaired by PGE2, a major product of cyclooxygenase-2 (COX-2), wh...
Background: Insulin sensitivity is impaired by PGE2, a major product of cyclooxygenase-2 (COX-2), wh...
Pathological angiogenesis is an essential component of tumor growth, development, and metastasis for...
The plasma membrane is highly organized and within the plasma membrane proteins cluster into so-call...
Drug-induced liver injury (DILI) is a common form of adverse drug reaction (ADR) seen within the cli...
Transcriptional regulation is an important component of the peripheral sensory neuronal response to ...
Malignant pleural mesothelioma (MPM) is a highly aggressive tumour arising from the mesothelial cell...
The E1B55k gene in adenovirus type 5 was studied by generating recombinant viruses in which the E1B5...