EPA guidance on assessment of negative symptoms in schizophrenia
- Galderisi, S
- Mucci, A
- Dollfus, S
- Nordentoft, M
- Falkai, P
- Kaiser, Stefan
- Giordano, G M
- Vandevelde, A
- Nielsen, M Ø
- Glenthøj, L B
- Sabe, Michel
- Pezzella, P
- Bitter, I
- Gaebel, W
DOIAbstract
During the last decades, a renewed interest for negative symptoms (NS) was brought about by the increased awareness that they interfere severely with real-life functioning, particularly when they are primary and persistent. In this guidance paper, we provide a systematic review of the evidence and elaborate several recommendations for the conceptualization and assessment of NS in clinical trials and practice
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