Context. M 33 is a gas rich spiral galaxy of the Local Group. Its vicinity allows us to study its interstellar medium (ISM) on linear scales corresponding to the sizes of individual giant molecular clouds.Aims. We investigate the relationship between the two major gas cooling lines and the total infrared (TIR) dust continuum.Methods. We mapped the emission of gas and dust in M 33 using the far-infrared lines of [C II] and [O I](63 μm) and the total infrared continuum. The line maps were observed with the PACS spectrometer on board the Herschel Space Observatory. These maps have 50 pc resolution and form a ∼370 pc wide stripe along its major axis covering the sites of bright H II regions, but also more quiescent arm and inter-arm regions fro...