Impact of maternal nutrition in viral infections during pregnancy

Other than being a physiological process, pregnancy is a condition characterized by major adaptations of maternal endocrine and metabolic homeostasis that are necessary to accommodate the fetoplacental unit. Unfortunately, all these systemic, cellular, and molecular changes in maternal physiology also make the mother and the fetus more prone to adverse outcomes, including numerous alterations arising from viral infections. Common infections during pregnancy that have long been recognized as congenitally and perinatally transmissible to newborns include toxoplasmosis, rubella, cytomegalovirus, and herpes simplex viruses (originally coined as ToRCH infections). In addition, enterovirus, parvovirus B19, hepatitis virus, varicella-zoster virus, human immunodeficiency virus, Zika and Dengue virus, and, more recently, coronavirus infections including Middle Eastern respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) infections (especially the novel SARS-CoV-2 responsible for the ongoing COVID-19 pandemic), constitute relevant targets for current research on maternal-fetal interactions in viral infections during pregnancy. Appropriate maternal education from preconception to the early postnatal period is crucial to promote healthy pregnancies in general and to prevent and/or reduce the impact of viral infections in particular. Specifically, an adequate lifestyle based on proper nutrition plans and feeding interventions, whenever possible, might be crucial to reduce the risk of virus-related gestational diseases and accompanying complications in later life. Here we aim to provide an overview of the emerging literature addressing the impact of nutrition in the context of potentially harmful viral infections during pregnancy.This work was supported by Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía, Spain (2020/275; CTS-584); Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT, grant number 1190316) and International Sabbatical (University Medical Centre Groningen, University of Groningen, The Netherlands) from the Vice-Rectorate of Academic Affairs, Academic Development Office of the Pontificia Universidad Católica de Chile, Chile. AS is recipient of an FPU predoctoral fellowship from Ministerio de Ciencia, Innovación y Universidades (FPU17/03465). CRG was supported by Ministerio de Ciencia e Innovación, Ayudas para la Promoción de Empleo Joven e Implantaci´on de la Garantía Juvenil en I+D+i 2017-2020 (PEJ2018-004474-A).Peer reviewe