Objective: To describe a possible novel genetic mechanism for cerebral small vessel disease (cSVD) and stroke.Methods: We studied a Swedish kindred with ischemic stroke and intracerebral hemorrhage, tremor, dysautonomia, and mild cognitive decline. Members were examined clinically, radiologically, and by histopathology. Genetic workup included whole-exome sequencing (WES) and whole-genome sequencing (WGS) and intrafamilial cosegregation analyses.Results: Fifteen family members were examined clinically. Twelve affected individuals had white matter hyperintensities and 1 or more of (1) stroke episodes, (2) clinically silent lacunar ischemic lesions, and (3) cognitive dysfunction. All affected individuals had tremor and/or atactic gait disturb...
Objective: Genome‐wide association studies (GWAS) have been successful at identifying associations w...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
A range of cardiovascular risk factors associated with stroke are known, but they do not explain all...
Objective: To describe a possible novel genetic mechanism for cerebral small vessel disease (cSVD) a...
Cerebral small vessel disease (CSVD) is the most important cause of vascular cognitive impairment (V...
Objective: Most lacunar strokes are sporadic, and hypertension, diabetes, smoking, and cardiovascula...
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is inco...
Abstract: Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic bas...
Cerebral small-vessel disease (SVD) is a well-known cause of stroke, dementia and death, but its pat...
Background: The pathogenesis of cerebral small-vessel disease (SVD) is still incompletely understood...
Monogenic forms of Alzheimer’s disease (AD) have been identified through mutations in genes such as ...
OBJECTIVES: To determine the frequency of rare and pertinent disease-causing variants in small vesse...
interest. Cerebral small vessel disease (SVD) is an important cause of stroke and cognitive impairme...
Pontine autosomal dominant microangiopathy and leukoencephalopathy (PADMAL) is a rare hereditary cer...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
Objective: Genome‐wide association studies (GWAS) have been successful at identifying associations w...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
A range of cardiovascular risk factors associated with stroke are known, but they do not explain all...
Objective: To describe a possible novel genetic mechanism for cerebral small vessel disease (cSVD) a...
Cerebral small vessel disease (CSVD) is the most important cause of vascular cognitive impairment (V...
Objective: Most lacunar strokes are sporadic, and hypertension, diabetes, smoking, and cardiovascula...
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is inco...
Abstract: Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic bas...
Cerebral small-vessel disease (SVD) is a well-known cause of stroke, dementia and death, but its pat...
Background: The pathogenesis of cerebral small-vessel disease (SVD) is still incompletely understood...
Monogenic forms of Alzheimer’s disease (AD) have been identified through mutations in genes such as ...
OBJECTIVES: To determine the frequency of rare and pertinent disease-causing variants in small vesse...
interest. Cerebral small vessel disease (SVD) is an important cause of stroke and cognitive impairme...
Pontine autosomal dominant microangiopathy and leukoencephalopathy (PADMAL) is a rare hereditary cer...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
Objective: Genome‐wide association studies (GWAS) have been successful at identifying associations w...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
A range of cardiovascular risk factors associated with stroke are known, but they do not explain all...