The vitreous humor is the first barrier encountered by intravitreally injected nanoparticles. Lipid-based nanoparticles in the vitreous are studied by evaluating their diffusion with single-particle tracking technology and by characterizing their protein coronae with surface plasmon resonance and high-resolution proteomics. Single-particle tracking results indicate that the vitreal mobility of the formulations is dependent on their charge. Anionic and neutral formulations are mobile, whereas larger (>200 nm) neutral particles have restricted diffusion, and cationic particles are immobilized in the vitreous. PEGylation increases the mobility of cationic and larger neutral formulations but does not affect anionic and smaller neutral particles...
AbstractWe are approaching a new era of retinal pharmacotherapy where new drugs are rapidly being wo...
Retinal eye diseases are the leading cause of blindness in the Western world. Up to date, the only e...
PURPOSE. Intravitreal injection of therapeutic DNA, complexed to nonviral carriers such as cationic ...
The vitreous humor is the first barrier encountered by intravitreally injected nanoparticles. Lipid-...
Posterior eye segment diseases, such as age-related macular degeneration, are leading causes of prev...
In this study, the intravitreal pharmacokinetics of nanomaterials were investigated in vivo in rats ...
In this dissertation, we covered three different topics focusing on ocular drug delivery for the tre...
The vitreous humor represents a significant barrier to the penetration of nanoparticulate-based ocul...
We are witnessing an exponential increase in the use of different nanomaterials in a plethora of bio...
AbstractThe efficient treatment of many ocular diseases depends on the rapid diffusive distribution ...
학위논문 (박사)-- 서울대학교 대학원 : 의학과 안과학 전공, 2016. 8. 박규형.Introduction: Recently, intravitreal injection of l...
Aim: To develop a robust assay to evaluate and compare the intravitreal mobility of nanoparticles in...
The purpose of this study is to develop a unique nanoparticulated system that has the capability of ...
This work has elucidated the potential of bio-inspired lipid nanoparticles for targeted retinal drug...
Aim: To develop a robust assay to evaluate and compare the intravitreal mobility of nanoparticles in...
AbstractWe are approaching a new era of retinal pharmacotherapy where new drugs are rapidly being wo...
Retinal eye diseases are the leading cause of blindness in the Western world. Up to date, the only e...
PURPOSE. Intravitreal injection of therapeutic DNA, complexed to nonviral carriers such as cationic ...
The vitreous humor is the first barrier encountered by intravitreally injected nanoparticles. Lipid-...
Posterior eye segment diseases, such as age-related macular degeneration, are leading causes of prev...
In this study, the intravitreal pharmacokinetics of nanomaterials were investigated in vivo in rats ...
In this dissertation, we covered three different topics focusing on ocular drug delivery for the tre...
The vitreous humor represents a significant barrier to the penetration of nanoparticulate-based ocul...
We are witnessing an exponential increase in the use of different nanomaterials in a plethora of bio...
AbstractThe efficient treatment of many ocular diseases depends on the rapid diffusive distribution ...
학위논문 (박사)-- 서울대학교 대학원 : 의학과 안과학 전공, 2016. 8. 박규형.Introduction: Recently, intravitreal injection of l...
Aim: To develop a robust assay to evaluate and compare the intravitreal mobility of nanoparticles in...
The purpose of this study is to develop a unique nanoparticulated system that has the capability of ...
This work has elucidated the potential of bio-inspired lipid nanoparticles for targeted retinal drug...
Aim: To develop a robust assay to evaluate and compare the intravitreal mobility of nanoparticles in...
AbstractWe are approaching a new era of retinal pharmacotherapy where new drugs are rapidly being wo...
Retinal eye diseases are the leading cause of blindness in the Western world. Up to date, the only e...
PURPOSE. Intravitreal injection of therapeutic DNA, complexed to nonviral carriers such as cationic ...