Add to ORKGA stereoselective and enantiodivergent strategy for the construction of δ-lactams is described. The strategy utilizes chiral malonic esters prepared from enantiomerically enriched mono esters of disubstituted malonic acid. A cyclization occurs with the selective displacement of a substituted benzyl alcohol as the leaving group. The resulting δ-lactams are then converted into nipecotic acid analogues using straightforward transformations. The resulting nipecotic acid analogues proved capable organocatalysts in Mannich reactions
A new strategy for catalytic enantioselective C-acylation to generate α-quaternary-substituted lacta...
YesThere is a need to develop asymmetric routes to functionalised β-lactams, which remain the most ...
The enantioselective synthesis of a N-benzyl substituted β-lactam, a precursor for carbapenem antibi...
A stereoselective and enantiodivergent strategy for the construction of δ-lactams is described. The ...
Prochiral malonic diesters consisting of a quaternary carbon center have been successfully converted...
A straightforward stereoselective and enantiodivergent cyclization strategy for the construction of ...
A straightforward stereoselective and enantiodivergent cyclization strategy for the construction of ...
A straightforward approach toward enantioenriched α-substituted α,β-unsaturated δ-lactams is describ...
C-fused γ-lactam-lactones are resident in several bioactive molecules, including anticancer agents s...
Using the chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition of dimethylzinc to acyc...
I. Enantio- and Diastereoselective Organocatalytic Conjugate Additions of Nitroalkanes to Enone Dies...
Cα-methyl-γ- and δ-unnatural amino acids (UAAs) are important class of biomolecules used extensively...
Starting from tricyclic lactam 2 , which is easily accessible by cyclocondensation of δ‐oxoester 1 w...
Grâce à leurs intérêts synthétiques, les réactions monotopes et domino stéréosélectives continuent à...
Amine Nucleophilic Addition to Nitro-alkene as a New Reaction Mode for the Synthesis of N-heterocycl...
A new strategy for catalytic enantioselective C-acylation to generate α-quaternary-substituted lacta...
YesThere is a need to develop asymmetric routes to functionalised β-lactams, which remain the most ...
The enantioselective synthesis of a N-benzyl substituted β-lactam, a precursor for carbapenem antibi...
A stereoselective and enantiodivergent strategy for the construction of δ-lactams is described. The ...
Prochiral malonic diesters consisting of a quaternary carbon center have been successfully converted...
A straightforward stereoselective and enantiodivergent cyclization strategy for the construction of ...
A straightforward stereoselective and enantiodivergent cyclization strategy for the construction of ...
A straightforward approach toward enantioenriched α-substituted α,β-unsaturated δ-lactams is describ...
C-fused γ-lactam-lactones are resident in several bioactive molecules, including anticancer agents s...
Using the chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition of dimethylzinc to acyc...
I. Enantio- and Diastereoselective Organocatalytic Conjugate Additions of Nitroalkanes to Enone Dies...
Cα-methyl-γ- and δ-unnatural amino acids (UAAs) are important class of biomolecules used extensively...
Starting from tricyclic lactam 2 , which is easily accessible by cyclocondensation of δ‐oxoester 1 w...
Grâce à leurs intérêts synthétiques, les réactions monotopes et domino stéréosélectives continuent à...
Amine Nucleophilic Addition to Nitro-alkene as a New Reaction Mode for the Synthesis of N-heterocycl...
A new strategy for catalytic enantioselective C-acylation to generate α-quaternary-substituted lacta...
YesThere is a need to develop asymmetric routes to functionalised β-lactams, which remain the most ...
The enantioselective synthesis of a N-benzyl substituted β-lactam, a precursor for carbapenem antibi...