Cassava plays a vital role in the world's tropical regions. However, it carries varying amounts of cyanogenic glucosides that are a possible human poison. Some forms of malpractices also endanger human health during production. This research assessed the human health issues related to cassava production and consumption. It described a comprehensive study on cassava roots as a staple carbohydrate and the leaves as vegetables containing vitamin and mineral sources but deficient in amino acids and proteins. It explained that cassava is an essential crop to food security and serves many great purposes economic stability. This work reveals that, cassava contains cyanogenic glycosides (Hydrogen cyanide; HCN) and other anti-nutritional properties...