15 pages, 1 figure, 22 references. Other author's papers can be downloaded at http://www.denys-dutykh.com/International audienceIn this short communication we present the multi-symplectic structure for the two-layer Serre-Green-Naghdi equations describing the evolution of large amplitude internal gravity long waves. We consider only a two-layer stratification with rigid bottom and lid for simplicity, generalisations to several layers being straightforward. This multi-symplectic formulation allows the application of various multi-symplectic integrators (such as Euler or Preissman box schemes) that preserve exactly the multi-symplecticity at the discrete level