Head and neck squamous cell cancer (HNSCC) associated with alcohol and tobacco consumption, and recently with human papillomavirus-16 (HPV-16), have bad prognosis despite current therapies. Development of innovative vaccine strategies and adequate pre-clinical tumor models are required to better evaluate HNSCCs. We developed a DNA vaccination that creates non-infectious virus-like particles, which express HPV-16 E7 oncoprotein (pVLP-E7). Results showed that pVLP-E7 induced an E7-specific immune response in vivo and in vitro. Moreover, using an ectopic model of HNSCC that expresses E6/E7 (TC-1), we found that pVLP-E7 intradermic (ID) immunizations induced anti-tumoral responses at early stages. For larger established tumors, pVLP-E7 vaccines...
Recombinant adenovirus or DNA vaccines encoding herpes simplex virus type 1 (HSV-1) glycoprotein D (...
Recombinant adenovirus or DNA vaccines encoding herpes simplex virus type 1 (HSV-1) glycoprotein D (...
Purpose: The induction of tissue-localized virus-specific CD8 T-cell response is essential for the d...
Head and neck squamous cell cancer (HNSCC) associated with alcohol and tobacco consumption, and rece...
Head and neck squamous cell cancer (HNSCC) associated with alcohol and tobacco consumption, and rece...
Head and neck squamous cell cancer (HNSCC) associated with alcohol and tobacco consumption, and rece...
Les cancers des voies aéro-digestives supérieures, liés à la consommation d'alcool et de tabac mais ...
High-risk human papillomavirus (HPV) encoding E6/E7-HPV oncogenes are responsible for a subgroup of ...
High-risk human papillomavirus (HPV) encoding E6/E7-HPV oncogenes are responsible for a subgroup of ...
De récents essais cliniques ont montré les bénéfices thérapeutiques des nouvelles immunothérapies (S...
Le cancer est la seconde cause de mortalité dans le monde et les cancers de localisation muqueuse (p...
Background/Aims: We have previously reported a recombinant vaccinia-based vaccine (vac-Sig/E7/LAMP-1...
Background and Objectives: Human papilloma virus (HPV) is known as the etiologic agent of cervical c...
Cancer is the second mortality cause worldwide while mucosal cancers (lung, stomac, …) is the first ...
Cancer is the second mortality cause worldwide while mucosal cancers (lung, stomac, …) is the first ...
Recombinant adenovirus or DNA vaccines encoding herpes simplex virus type 1 (HSV-1) glycoprotein D (...
Recombinant adenovirus or DNA vaccines encoding herpes simplex virus type 1 (HSV-1) glycoprotein D (...
Purpose: The induction of tissue-localized virus-specific CD8 T-cell response is essential for the d...
Head and neck squamous cell cancer (HNSCC) associated with alcohol and tobacco consumption, and rece...
Head and neck squamous cell cancer (HNSCC) associated with alcohol and tobacco consumption, and rece...
Head and neck squamous cell cancer (HNSCC) associated with alcohol and tobacco consumption, and rece...
Les cancers des voies aéro-digestives supérieures, liés à la consommation d'alcool et de tabac mais ...
High-risk human papillomavirus (HPV) encoding E6/E7-HPV oncogenes are responsible for a subgroup of ...
High-risk human papillomavirus (HPV) encoding E6/E7-HPV oncogenes are responsible for a subgroup of ...
De récents essais cliniques ont montré les bénéfices thérapeutiques des nouvelles immunothérapies (S...
Le cancer est la seconde cause de mortalité dans le monde et les cancers de localisation muqueuse (p...
Background/Aims: We have previously reported a recombinant vaccinia-based vaccine (vac-Sig/E7/LAMP-1...
Background and Objectives: Human papilloma virus (HPV) is known as the etiologic agent of cervical c...
Cancer is the second mortality cause worldwide while mucosal cancers (lung, stomac, …) is the first ...
Cancer is the second mortality cause worldwide while mucosal cancers (lung, stomac, …) is the first ...
Recombinant adenovirus or DNA vaccines encoding herpes simplex virus type 1 (HSV-1) glycoprotein D (...
Recombinant adenovirus or DNA vaccines encoding herpes simplex virus type 1 (HSV-1) glycoprotein D (...
Purpose: The induction of tissue-localized virus-specific CD8 T-cell response is essential for the d...