Ki-67 nuclear antigen as a prognostic factor in renal cell carcinoma

Great attention paid to renal cell carcinoma (RCC) is due to increase in its prevalence. This paper is devoted to comparison of classic clinical and pathological prognostic factors and expression character of proliferation marker Ki-67 in this cancer. Proliferative activity was analyzed in 101 cases of RCC by immunohistochemical assays using antibodies to the Ki-67. High index Ki-67 was diagnosed more often in an aggressive variants RCC and Fuhrman grade 3–4 tumors. Besides, RCC with high proliferative activity had significantly lower time of appearance of distant metastases and poor survival in coparison with RCC with low proliferative activity