Expression of KI67, P53 and MUC1 in Renal Cell Carcinoma in Correlation with Nuclear Grade

AIMS AND OBJECTIVES: Renal cell carcinoma comprises 2-3% of adult malignancies. It has been very challenging to predict the prognosis of each of the patients with RCC; when assessing cancer prognosis, classic prognostic factors, staging and grading were also not always accurate in prediction. In different studies, Ki67, p53 and MUC1 have been considered as a good predictive marker for RCC aggression, prognosis and survival outcome of patients. In this study, an attempt has been made to compare the expression of Ki67, p53 and MUC1 markers with nuclear grade and other clinicopathological parameters. MATERIALS AND METHODS: The clinical and pathological findings of Renal cell carcinoma cases were retrieved from the pathology records from august 2011 to august 2014 in Rajiv Gandhi Government General Hospital, Chennai. Totally 52 cases of renal cell carcinoma was studied and of this, 40 cases were randomly selected and immunohistochemistry was done using Ki67, p53, and MUC1. RESULTS: Among 52 cases studied, 36 were clear cell RCC, 8 were papillary RCC, 2 were Chromophobe RCC, 6 were unclassified RCC. Most common nuclear grade was Furhman nuclear grade 3. There was statistically significant association of Ki67 expression with nuclear grade and stage at presentation. Association between p53 and histological type was found to be significant. There is significant association of MUC1 expression with nuclear grade and stage. CONCLUSION: The combined detection of Ki67, p53 and MUC1 expressions, which are superior to single marker along with nuclear grade and stage, could be used to significantly improve the accuracy in predicting the prognosis of RCC patients