Biochemical studies on basophil leucocytes

Several variables associated with the assimilation of histamine by the guinea pig basophil have been studied. The experimental model has been an in vitro technique which measures the uptake of radiolabelled histidine and histamine, and the synthesis of new histamine from the isotopic histidine incorporated. The cell preparations used were prepared by modifications of previously published procedures for obtaining large numbers of basophils from the bone marrow of the guinea pig