Histone Shock and The Relation between

The relation between protease and nucleoprotein(histone) is described on the point of anaphylactoid shock in guinea pigs. Histone caused the anaphylactoid shock in guinea pigs, but histone with plasmin incubated for twenty-four hours did not. Histone released the histamine significantly from the mast cells. The mechanism of anaphylactic and anaphylactoid phenomenon has been done experimenting and many theories have been advocated. Among them protease theories (1, 2) have called much attention to the possi-bility of explaining histamine release as the resulting from the activation of proteolytic enzymes. Many evidences have been accumulated that the protease activity increases on the antigen-antibody reaction (3-6), tissue injuries (7, 8) and other (9). Plasmin, however, has an important weak point, because of less histamine release from the tissue (10, 11). The object of the work which is reported in this paper was to inve-stigate histone shock on guinea pigs and the relation between plasmi