Study of Clinical Profile of Organophosphorous Compound Poisoning with Special Reference to Electrocardiographic Changes

INTRODUCTION: Most common electrocardiographic abnormalities associated with the organophosphate poisoning with sinus tachycardia, sinus bradycardia, QTc prolongation, ST-T shifts, and a variety of arrhythmias, some of which can be deadly and serious. Myocardiotoxic injury from organophosphate poisoning has been hypothesised to occur in both animal and human research (myocardial necrosis). Organophosphate chemical poisoning has been linked to structural cardiac damage and electrocardiographic abnormalities. If detected early and properly managed, many consequences may be avoidable. OBJECTIVES: To study the clinical profile, Electrocardiographic changes and its prognostic significance among patients with organophosphorus compound poisoning. METHODOLOGY: This is a Prospective observational study among 89 patients admitted with organophosphate poisoning, under the Department of General Medicine, Thanjavur Medical College. A thorough, in-depth history was obtained from the subjects, including the clinical profile, findings, ECG changes and outcomes were analyzed. RESULTS: In this study All the subjects had sinus rhythm in ECG. 43 (43%) had Normal rate, 35 (35%) had Sinus tachycardia and 22 (22%) had Sinus bradycardia. 93 (93%) had Nil Conduction Defects and 7 (7%) had PR prolonged in ECG. 60 (60%) had Nil ST changes, 18 (18%) had QT prolongation and 12 (12%) had ST depression. Mortality rate were significantly higher, when the with the presence of QT prolongation and ST depression. Each unit increase in Duration between Ingestion & Admission (hours) had increase of risk of death by 2.24 times. Compared to normal level of consciousness, Drowsy or stupurous level of consciousness had 45.3 odds of getting death. CONCLUSION: ECG can play a significant role in identification of the high-risk population among the patients with OPC poisoning and the mortality rates can be reduced