AN ANALYTICAL STUDY ON THE RATE OF MORTALITY BECAUSE OF ORGANOPHOSPHORUS POISONING

Objective: There is very high rate of morbidity as well as mortality because of OP (Organophosphorus) poisoning. The aim of this research work is to assess the rate of mortality because of OP poisoning. Methodology: This elaborate & analytical research work carried out in the Medical unit & ICU of Mayo Hospital Lahore from November 2018 to April 2019. All the patients under suspicion of organophosphorus poisoning got admission in the hospital. We recorded the history & medical aspects of these patients. The standard of the diagnosis of this research work was history of the patients from their parent about the intake of OP poison & medical symptoms as too much bradycardia, salivation, wheezing & meiosis. The patients without the symptom of meiosis & patients who expired in the department of emergency before their arrival in the ICU or medical ward were not the part of this research work. SPSS V. 11 was in use for the statistical analysis of the collected information. Results: In the duration of this research work, we studied the hundred patients with conform OP poisoning and we divided these patients according to the severity grades. The average age of the patients was 43 years. Seventy-eight percent were male and twenty-two were female patients. Twenty patients were in the group of mild severity, 40 patients were in the group of moderate severity and forty patients were in the group of severe grades. The most frequent site for exposure to OP poison was ingestion in 79.0% (n: 79), followed by inhalation & dermal absorption in 21.0% (n: 21). The clinical aspects like hyper salivation, metal state of depression, meiosis and wheezing were present in all hundred patients followed by lacrimation in 90.0% (n: 90), bradycardia in 58.0% (n: 58), hypotension in 76.0% (n: 76), chest crepitation in 80.0% (n: 80), vomiting in 69.0% (n: 69), cramps in abdomen cavity in 40.0% (n: 40). We saw the failure of the respiratory system in 42.0% (n: 42), sepsis in 5.0% (n: 5), seizures in 9.0% (n: 9), Pulmonary edema present in 19.0% (n: 19) & ARDS in 10.0% (n: 10) patients. Mean duration of stay in the hospital was 4.5 0 ± 2.50. The rate of mortality in this research work was 18%. Respiratory failure was the main reason of death in this research work. Conclusion: The rate of mortality because of OP poisoning is very high in these regions. The early and easy diagnosis is possible with the identification of the clinical factors. KEY WORDS: Poison, Organophosphorus, Mortality, Pesticides, Hypotension, Toxicity & Deaths, Diagnosis