In Chap. 5, have been explained the architectural choices for the design of the signal conditioning chain for smart sensors based on the application addressed and on the electrical characteristics of the TFTs manufactured on foil. In this chapter, each of the blocks in the signal conditioning chain is discussed separately, providing a deeper insight in the technology-aware circuit design techniques that have been developed to improve robustness and performance. Following the signal through the front-end path, the low-pass filter is introduced first, and then the continuous-time and the discrete-time amplifiers