Secure communication is of paramount importance in modern society. Asymmetric cryptography methods such as the widely used RSA cryptosystem allow secure exchange of information between parties who have never previously shared keys. However, the existing asymmetric cryptographic schemes rely on unproven mathematical assumptions for security. Further, the digital keys used in their implementation are susceptible to copying that might remain unnoticed. Here, we introduce a secure communication method based on Physical Unclonable Keys (PUKs), which we call PUK- Enabled Asymmetric Communication (PEAC). PEAC uses physical keys and thus overcomes the problem of unnoticed copying. As all the information about the PUK is allowed to be public, PEAC d...