Physical Unclonable Functions (PUFs) are physical structures that are hard to clone and have a unique challenge-response behaviour. The term PUF was coined by Pappu et al. in 2001. That work triggered a lot of interest, and since then a substantial number of papers has been written about the use of a wide variety of physical structures for different security purposes such as identification, authentication, read-proof key storage, key distribution, tamper evidence, anti-counterfeiting, software-to-hardware binding and trusted computing. In this paper we propose a new security primitive: the quantum-readout PUF (QRPUF). This is a classical PUF which is challenged using a quantum state, e.g. a single-photon state, and whose response is also a ...