In this article I explore naturalism as a joyful science by focusing on how Nietzsche and Deleuze appropriate an Epicurean legacy. In the first section I introduce some salient features of Epicurean naturalism and highlight how the study of nature is to guide ethical reflection on the art of living. In the next section I focus on Nietzsche and show the nature and extent of his Epicurean commitments in his middle period writings. In the third and final main section my attention shifts to Deleuze and to showing how he fruitfully demonstrates the intersection of physics and ethics in the Epicurean method of thinking. I am interested in Epicureanism since, as both Nietzsche and Deleuze show, it holds ethics to be central to philosophical inquir...