A naturalistic conception of things is a great work of imagination – greater, I think, than any dramatic or moral mythology: it is a conception fit to inspire great poetry, and in the end, perhaps, it will prove the only conception able to inspire it. (Santayana) ABSTRACT: In this essay I explore the nature of Deleuze’s commitment to an affirmative naturalism that is based on certain Epicurean principles and insights. The essay is divided into two main parts. In the first part I bring to light some of the key features of Lucretius’s great poem on the nature of things, and I do so with the aid of Bergson and his reading of the teaching as fundamentally melancholic. In the second part I switch my attention to Deleuze and show how he links tog...