THE PLASTICITY OF HEMO- AND ELECTRO-EXCITING NEURON MEMBRANES: THE REGULATION BY THE OPIOIDS AND SECONDARY MEDIATORS

The object of investigation: the edible and garden snails, optic cortex of the front and the cover of the middle brain of the fresh-water turtle. The universal mechanism of plasticity of the hemo- and electro-excited membranes, including the change of its excitation, has been shown. For the first time, the correlation of the cholinoreceptive membranes degree of plasticity with the ratio of the cholinoreceptors, controlling the conductance of the different ions, has been shown. First it has been shown, that the direction and the degree of modulation of plasticity of the hemoexciting membranes of the neuron by the opioids is being determined with the type of the activated opiate receptors and with the character of its intereffects. Shown for the first time are the multi-link regulating molecular mechanisms of the cholinoreceptors plasticity, various-directed modulation of the cholinoreceptors plasticity by the acyclic eicosanoid-15-hydroxyeicosatetraenic acid, weakening of the cholinoreceptors plasticity with the opiate cappa-agonist bremasocyne, braking the cholinoreceptors with the endogenic peptide of the mollusks SKRYMRF-amide, which encounter the intracellular ways, containing some secondary mediators, changing the concentration of the free calcium in the cytoplasma. The results have been introduced in the study process of the Moscow State University.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio