THE ELECTROPHYSIOLOGICAL ANALYSIS OF THE MEMBRANE MECHANISMS OF THE LONG-TERM SENSITIZATION

The object of investigation: edible snail Helix Pomatia, its giant neurons LPa2,3 and RPa2,3 (the command neurons of the protective behaviour). The purpose of the work: the revealation of the membrane mechanisms of the postsynaptic variations in the formation of the prolonged sensitization on the identified command neurons of the protective behaviour of Helix Pomatia. Obtained have been the data about the variation of the postsynaptic neurons membran excitation, about the increase of the rest potential with the working of the prolonged sensitization, about the detected phenomenon of the depolarization accumulation with the successive stimulation. The mathematical model of the somatic membrane excitation has been developed. The results of the work deepen the fundamental representations about the cellular mechanisms of plasticity and can be used in the investigation of action of the biologically active substances in the different model situations on the simple cellular model of the prolonged sensitization, and in reading the courses of lectures by the neurophysiologyAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio