We consider the uniqueness of solution (i.e., nonsingularity) of systems of r generalized Sylvester and ⋆‐Sylvester equations with n×n coefficients. After several reductions, we show that it is sufficient to analyze periodic systems having, at most, one generalized ⋆‐Sylvester equation. We provide characterizations for the nonsingularity in terms of spectral properties of either matrix pencils or formal matrix products, both constructed from the coefficients of the system. The proposed approach uses the periodic Schur decomposition and leads to a backward stable O(n3r) algorithm for computing the (unique) solution.Ministerio de Economía y Competitividad of Spain. Grant Numbers: MTM2015-68805-REDT, MTM2015- 65798-P; Istituto Nazionale di Alt...