Nontyphoidal Salmonella enterica (NTS) infections are a major burden to global public health, as they lead to diseases ranging from gastroenteritis to systemic infections and there is currently no vaccine available. Here, we describe a highly effective component vaccine against S. enterica serovar Typhimurium in both gastroenteritis and systemic murine infection models. We devised an approach to generate supernatants of S. enterica serovar Typhimurium, an organism that is highly abundant in virulence factors. Immunization of mice with this supernatant resulted in dramatic protection against a challenge with serovar Typhimurium, showing increased survival in the systemic model and decreased intestinal pathology in the gastrointestinal model....
Salmonella (S.) enterica infections are an important global health problem affecting mainly low-inco...
Immunity to Salmonella enterica serovar Typhimurium (STm) is complex and requires both cell mediated...
Pseudomonas aeruginosa is a common Gram-negative opportunistic pathogen that is intrinsically resist...
Salmonella enterica subspecies enterica includes several serovars infecting both humans and other an...
Among more than 2500 nontyphoidal Salmonella enterica (NTS) serovars, S. enterica serovar Typhimuriu...
Salmonella enterica serovar Typhimurium has been extensively exploited as live attenuated vaccines (...
Salmonella enterica serovar Typhimurium has long been recognised as a zoonotic pathogen of economic ...
Non-typhoidal Salmonella (NTS) serovars S. Enteritidis and S. Typhimurium are a major cause of invas...
Salmonella Typhi and Salmonella Paratyphi A are the leading causative agents of enteric fever which ...
Introduction: Globally, Salmonella enterica serotype Typhi is responsible for more than 10 million e...
Live attenuated vaccines are superior to the killed or subunit vaccines. We designed a Salmonella Ty...
A prevalent food-borne pathogen, Salmonella enterica serotypes Typhi, is responsible for gastrointes...
Salmonella Typhi and Salmonella Paratyphi A are the leading causative agents of enteric fever which ...
Salmonella enterica subsp. enterica includes several very important human serovars including Typhi, ...
The superiority of live attenuated vaccines in systemic salmonellosis has been proven over killed an...
Salmonella (S.) enterica infections are an important global health problem affecting mainly low-inco...
Immunity to Salmonella enterica serovar Typhimurium (STm) is complex and requires both cell mediated...
Pseudomonas aeruginosa is a common Gram-negative opportunistic pathogen that is intrinsically resist...
Salmonella enterica subspecies enterica includes several serovars infecting both humans and other an...
Among more than 2500 nontyphoidal Salmonella enterica (NTS) serovars, S. enterica serovar Typhimuriu...
Salmonella enterica serovar Typhimurium has been extensively exploited as live attenuated vaccines (...
Salmonella enterica serovar Typhimurium has long been recognised as a zoonotic pathogen of economic ...
Non-typhoidal Salmonella (NTS) serovars S. Enteritidis and S. Typhimurium are a major cause of invas...
Salmonella Typhi and Salmonella Paratyphi A are the leading causative agents of enteric fever which ...
Introduction: Globally, Salmonella enterica serotype Typhi is responsible for more than 10 million e...
Live attenuated vaccines are superior to the killed or subunit vaccines. We designed a Salmonella Ty...
A prevalent food-borne pathogen, Salmonella enterica serotypes Typhi, is responsible for gastrointes...
Salmonella Typhi and Salmonella Paratyphi A are the leading causative agents of enteric fever which ...
Salmonella enterica subsp. enterica includes several very important human serovars including Typhi, ...
The superiority of live attenuated vaccines in systemic salmonellosis has been proven over killed an...
Salmonella (S.) enterica infections are an important global health problem affecting mainly low-inco...
Immunity to Salmonella enterica serovar Typhimurium (STm) is complex and requires both cell mediated...
Pseudomonas aeruginosa is a common Gram-negative opportunistic pathogen that is intrinsically resist...