Endothelium-, soluble guanylyl cyclase-dependent contractions in isolated arteries

Conference Theme: Bridging Translational GapOral Presentation: no. OP3OBJECTIVES: This study focuses on the effects of thymoquinone on isolated arteries, by determining the mechanisms underlying the endothelium- and soluble guanylyl cyclase (sGC)-dependent augmentation of contraction that this natural compound causes, comparable to the augmentation described under hypoxic conditions. METHODS: Experiments were designed to study the effect of thymoquinone ex vivo in isolated porcine coronary and rat arteries. Rings, with or without endothelium, were suspended in ...postprin