Effects of WY14643 and fenofibrate on acetylcholine-induced contractions in aortic rings from spontaneously hypertensive rats

Conference Theme: Bridging Translational GapChaired Posters: no. CP5INTRODUCTION AND OBJECTIVE: Oxidative stress is implicated in the release of endothelium-derived contracting factors, the release of which is associated with endothelial dysfunction. Peroxisome proliferator-activated receptor (PPAR) –alpha agonists, Wy14643 (WY) and fenofibrate (FF) have been found improving endothelial function in cardiovascular diseases. The present study was designed to examine whether or not WY and FF inhibit endothelium-dependent contractions through reduction of free ...postprin