The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro
- Xiao, J
- Youdim, M
- Liong, EC
- Pan, J
- Guo, R
- Fung, ML
- So, KF
- Lin, B
- Tipoe, GL
Publication date
January 2013
DOI Publisher
Springer Science and Business Media LLC Journal
Hepatology InternationalAbstract
Topic: 2 Acute Liver FailureThis journal suppl. entitled: APASL Liver Week 2013BACKGROUND/AIMS: The novel multifunctional brain permeable ironchelator M30 possesses neuroprotective activities against several insults applicable to various neurodegenerative diseases. However, the effect of M30 on CCl4 induced acute liver damage is still unknown. The aim of this study is to investigate whether the multifunctional drug M30 could ameliorate CCl4 induced hepatic injury in human HepG2 cell line. METHODS: HepG2 cells were grown in DMEM supplemented with ...postprin
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