The purpose of this paper is to compare two of the most commonly employed methods employed to measure the Intellectual Capital (IC) value: Market to Book (MtB) ratio and the VAIC, in order to determine the most suitable in the context of Italian listed firms and their respective relationships with some key IC determinants. The study is conducted for a sample of Italian listed firms over the period 2009-2014. Different tests are employed to compare VAIC and MtB, while, two linear panel regression models with fixed effects models are performed in order to test the relationship between IC value and selected determinants. Results suggest that the MtB ratio is a better estimator of IC value than VAIC. For MtB, IA and profitability-are significan...