Beyond the influence of idh mutations: Exploring epigenetic vulnerabilities in chondrosarcoma
- Venneker, S. (Sanne)
- Kruisselbrink, A.B. (Alwine B.)
- Baranski, Z. (Zuzanna)
- Palubeckaite, I. (Ieva)
- Briaire-de Bruijn, I.H. (Inge H.)
- Oosting, J. (Jan)
- French, P.J. (Pim)
- Danen, E.H.J. (Erik H. J.)
- Bovée, J.V.M.G. (Judith)
Publication date
December 2020
DOIAbstract
Mutations in the isocitrate dehydrogenase (IDH1 or IDH2) genes are common in enchondromas and chondrosarcomas, and lead to elevated levels of the oncometabolite D-2-hydroxyglutarate causing widespread changes in the epigenetic landscape of these tumors. With the use of a DNA methylation array, we explored whether the methylome is altered upon progression from IDH mutant enchondroma towards high-grade chondrosarcoma. High-grade tumors show an overall increase in the number of highly methylated genes, indicating that remode
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