Acetaminophen (AAP) overdose can cause severe liver injury and liver failure in experimental animals and humans. Recently, several authors proposed that apoptosis might be a major mechanism of cell death after AAP treatment. To address this controversial issue, we evaluated a detailed time course of liver injury after AAP (300 mg/kg) in fasted C3Heb/FeJ mice. Apoptotic hepatocytes were quantified in H&E-stained liver sections using morphologic criteria (cell shrinkage, chromatin condensation and margination, and apoptotic bodies). The number of apoptotic hepatocytes remained at baseline (0.2 ± 0.1 cells/10 high-power fields [HPF]) up to 2 h after AAP administration. However, between 3 and 24 h, apoptotic cell death increased significantly, ...
Drug-induced liver injury is an important clinical problem and a challenge for drug development. Whe...
Introduction\ud Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP...
<div><p>Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in human...
Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in ...
Acetaminophen (AAP) is widely prescribed for treatment of mild pain and fever in western countries. ...
Repeated administration of hepatotoxicants is usually accompanied by liver fibrosis. However, the di...
Paracetamol (Acetaminophen, N-acetyl-p-aminophenol, AAP) is a popular domestic analgesic and antipyr...
In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver fai...
Paracetamol (Acetaminophen, N-acetyl-p-aminophenol, AAP) is a popular domestic analgesic and antipyr...
Paracetamol is very widely used as an analgesic drug. However at massive doses it causes liver failu...
Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mecha...
Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often...
Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often...
In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver fai...
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as ...
Drug-induced liver injury is an important clinical problem and a challenge for drug development. Whe...
Introduction\ud Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP...
<div><p>Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in human...
Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in ...
Acetaminophen (AAP) is widely prescribed for treatment of mild pain and fever in western countries. ...
Repeated administration of hepatotoxicants is usually accompanied by liver fibrosis. However, the di...
Paracetamol (Acetaminophen, N-acetyl-p-aminophenol, AAP) is a popular domestic analgesic and antipyr...
In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver fai...
Paracetamol (Acetaminophen, N-acetyl-p-aminophenol, AAP) is a popular domestic analgesic and antipyr...
Paracetamol is very widely used as an analgesic drug. However at massive doses it causes liver failu...
Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mecha...
Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often...
Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often...
In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver fai...
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as ...
Drug-induced liver injury is an important clinical problem and a challenge for drug development. Whe...
Introduction\ud Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP...
<div><p>Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in human...