Determination of Ketoconazole in Pharmaceutical Formulations

Ketoconazole has been widely used as an antifungal drug that is formulated as tablets, cream and over-the-counter ketoconazole shampoo. The aim of this research was to study and to standardize an UV (ultraviolet spectrophotometric) method, potentiometry and a HPLC (high performance liquid chromatographic) method for the determination of ketoconazole in commercially available tablets. These three methods were compared and discussed with respect to their sensitivity, selectivity and ready-applicability in routine analytical work. Absorption spectra and spectrophotometric determinations were carried out on the UV spectrophotometer. Investigated concentrations that ranged from 0.003 mg•dm-3 to 0.02 mg•dm-3