Recent insights into zebrafish cardiac regeneration.

In humans, myocardial infarction results in ventricular remodeling, progressing ultimately to cardiac failure, one of the leading causes of death worldwide. In contrast to the adult mammalian heart, the zebrafish model organism has a remarkable regenerative capacity, offering the possibility to research the bases of natural regeneration. Here, we summarize recent insights into the cellular and molecular mechanisms that govern cardiac regeneration in the zebrafish.This work was supported by the European Research Council ERC Consolidator Grant 819717 – TransReg and the Swiss National Science Foundation grant ForceInRegeneration 310030L_182575.S