LOX-1-mediated effects on vascular cells in atherosclerosis

In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly upregulated in vascular cells. In atherosclerosis, LOX-1 appears to be the key scavenger receptor for binding oxidized LDL (oxLDL). Notably, a positive feedback exists between LOX-1 and oxLDL. LOX-1 is involved in mediating of proatherosclerotic effects of oxLDL which result inendothelial dysfunction, proinflammatory recruitment of monocytes into the arterial intima,formation of foam cells, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells(VSMCs), as well as in plaque destabilization and rupture. In this review, we consider effects ofthe LOX-1/oxLDL axis on several types of vascular cells such as ECs, VSMCs, and macrophages