Editorial: Transplant rejection and tolerance-advancing the field through integration of computational and experimental investigation

Seventy years after the first proof of concept that the immune system can be trained to accept transplanted tissues via induction of immune tolerance, we are still waiting for a clinical approach that could be used routinely in transplant patients. Transplantation is a life-saving surgical procedure that is still only successful when paired with life-long administration of immunosuppressive drugs. However, the debilitating side effects of the long-term use of these drugs, together with their incomplete control of the immune system, compromise the quality of life and survival of transplant recipients. Thus, there is a strong push to find new therapeutic strategies that promote indefinite acceptance of a transplanted tissue without compromising the effectiveness of the patient’s immune system. Although many exciting ideas have been explored, none of the resulting strategies have been successfully converted into a widely applicable therapeutic approach