5-15% of lymphocytes in the peritoneums of normal adult B10.H-2aH- 4bp/Wts (2a4b) mice are CD5+ (Ly-1) B cells that recognize phosphatidyl choline (PtC), a phospholipid component of all mammalian cells. We produced a set of IgM-secreting hybridomas from the peritoneal cells of normal, adult 2a4b mice. We found that this set of hybridomas shows a similarly high frequency of antibodies specific for PtC (21 of 86) that also react with bromelain-treated mouse erythrocytes. Restriction fragment analysis of Ig gene rearrangements and analysis of expressed Ig idiotypes reveal that these cells use a restricted set of variable region genes to generate the PtC-specific antibodies. The Ig genes used by the PtC-specific hybridomas appear to be the same...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...
5-15% of lymphocytes in the peritoneums of normal adult B10.H-2aH- 4bp/Wts (2a4b) mice are CD5+ (Ly-...
Adult mice have two easily recognizable subsets of B cells: the predominant resting population of th...
Adult mice have two easily recognizable subsets of B cells: the predominant resting population of th...
We have found that, in the peritoneums of normal adult mice, 5-15% of lymphocytes bind a fluorescent...
We have found that, in the peritoneums of normal adult mice, 5-15% of lymphocytes bind a fluorescent...
A series of 27 B-cell lymphomas (designated the CH series), induced in B10.H-2aH-4b p/Wts mice by in...
A series of 27 B-cell lymphomas (designated the CH series), induced in B10.H-2aH-4b p/Wts mice by in...
Benign monoclonal gammapathy (BMG) is defined as a benign monoclonal B cell proliferative disorder c...
Benign monoclonal gammapathy (BMG) is defined as a benign monoclonal B cell proliferative disorder c...
Benign monoclonal gammapathy (BMG) is defined as a benign monoclonal B cell proliferative disorder c...
Murine phosphatidyl choline (PtC)–specific B cells in normal mice belong exclusively to the B-1 subs...
Murine phosphatidyl choline (PtC)–specific B cells in normal mice belong exclusively to the B-1 subs...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...
5-15% of lymphocytes in the peritoneums of normal adult B10.H-2aH- 4bp/Wts (2a4b) mice are CD5+ (Ly-...
Adult mice have two easily recognizable subsets of B cells: the predominant resting population of th...
Adult mice have two easily recognizable subsets of B cells: the predominant resting population of th...
We have found that, in the peritoneums of normal adult mice, 5-15% of lymphocytes bind a fluorescent...
We have found that, in the peritoneums of normal adult mice, 5-15% of lymphocytes bind a fluorescent...
A series of 27 B-cell lymphomas (designated the CH series), induced in B10.H-2aH-4b p/Wts mice by in...
A series of 27 B-cell lymphomas (designated the CH series), induced in B10.H-2aH-4b p/Wts mice by in...
Benign monoclonal gammapathy (BMG) is defined as a benign monoclonal B cell proliferative disorder c...
Benign monoclonal gammapathy (BMG) is defined as a benign monoclonal B cell proliferative disorder c...
Benign monoclonal gammapathy (BMG) is defined as a benign monoclonal B cell proliferative disorder c...
Murine phosphatidyl choline (PtC)–specific B cells in normal mice belong exclusively to the B-1 subs...
Murine phosphatidyl choline (PtC)–specific B cells in normal mice belong exclusively to the B-1 subs...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 1...