The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects
- Alexis, Neil E.
- Zhou, Haibo
- Lay, John C.
- Harris, Bradford
- Hernandez, Michelle L.
- Lu, Tsui Shan
- Bromberg, Philip A.
- Diaz-Sanchez, David
- Devlin, Robert B.
- Kleeberger, Steven R.
- Peden, David B.
Publication date
January 2009
DOIAbstract
The Glutathione-S-Transferase Mu 1 null genotype has been reported to be a risk factor for acute respiratory disease associated with increases in ambient air ozone. Ozone is known to cause an immediate decrease in lung function and increased airway inflammation. However, it is not known if GSTM1 modulates these ozone responses in vivo in human
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