The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent CDK4 and CDK6 and induces the growth-suppressive function of Rb family proteins. Mutations in the Cdk4 gene conferring INK4 resistance are associated with familial and sporadic melanoma in humans and result in a wide spectrum of tumors in mice, suggesting that INK4 is a major regulator of CDK4. Mice lacking the Cdk4 gene exhibit various defects in many organs associated with hypocellularity, whereas loss of the p18Ink4c gene results in widespread hyperplasia and organomegaly. To genetically test the notion that the function of INK4 is dependent on CDK4, we generated p18; Cdk4 double-mutant mice and examined the organs and tissues which develo...
AbstractThe INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinas...
Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-depende...
AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...
The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent ...
The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent ...
The presence of two families of seven distinct mammalian cyclin-dependent kinase (CDK) inhibitor gen...
AbstractThe cell cycle inhibitor p16INK4a is inactivated in many human tumors and in families with h...
Progression through the G1, S, G2 and M phases of the cell cycle is controlled by cyclin-dependent k...
Pituitary tumors develop in about one-quarter of the population, and most arise from the anterior lo...
Cell cycle progression from G1 to S phase depends on phosphorylation of pRb by complexes containing ...
Inactivation of the Rb-mediated G1 control pathway is a common event found in many types of human tu...
Abstractp16INK4a, p15INK4b, p18INK4c and p19INK4d comprise a family of cyclin-dependent kinase inhib...
The presence of two families of seven distinct mammalian cyclin-dependent kinase (CDK) inhibitor gen...
Mutant mice lacking both cyclin-dependent kinase (CDK) inhibitors p18Ink4c and p27Kip1 develop a tum...
Cell cycle progression from G1 to S-phase depends on phosphorylation of pRb by complexes containing ...
AbstractThe INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinas...
Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-depende...
AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...
The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent ...
The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent ...
The presence of two families of seven distinct mammalian cyclin-dependent kinase (CDK) inhibitor gen...
AbstractThe cell cycle inhibitor p16INK4a is inactivated in many human tumors and in families with h...
Progression through the G1, S, G2 and M phases of the cell cycle is controlled by cyclin-dependent k...
Pituitary tumors develop in about one-quarter of the population, and most arise from the anterior lo...
Cell cycle progression from G1 to S phase depends on phosphorylation of pRb by complexes containing ...
Inactivation of the Rb-mediated G1 control pathway is a common event found in many types of human tu...
Abstractp16INK4a, p15INK4b, p18INK4c and p19INK4d comprise a family of cyclin-dependent kinase inhib...
The presence of two families of seven distinct mammalian cyclin-dependent kinase (CDK) inhibitor gen...
Mutant mice lacking both cyclin-dependent kinase (CDK) inhibitors p18Ink4c and p27Kip1 develop a tum...
Cell cycle progression from G1 to S-phase depends on phosphorylation of pRb by complexes containing ...
AbstractThe INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinas...
Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-depende...
AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...